Best dog anxiety supplements

January 7, 2022

Vets recommend the best soothing supplements for dogs

We began with brands that are committed to quality – we excluded any brands that do not actively employ a veterinarian (or pet nutritionist) or undertake efficacy research on their own products.

We concentrated on items with a proven track record – we asked our veterinarians which soothing supplements they recommend to their patients and why. Surprisingly, the recommendations were nearly same across the board.

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The fundamentals

OTC calming supplements for dogs are generally safe if taken as directed on the package. The effectiveness varies depending on the dog and the level of his or her nervousness.

Anxiety is classified into two types: persistent anxiety and situational anxiety. The way you treat your dog is determined by the type of anxiety they experience.

Anxiety in dogs is a common misdiagnosis. Dogs who aren't adequately exercised have a lot of pent-up energy. As a result, the dog becomes restless and develops anxiety-like symptoms. Unfortunately, vets see this all the time.

There are numerous supplements available for dogs these days, for conditions ranging from liver and kidney illness to arthritis and even anxiety. With so many items claiming to assist address your pet's health concerns, it's difficult to determine which ones to invest in. And it can be difficult to tell if they function at all.

Most vitamins are "over the counter," which means you don't need a veterinarian's prescription to get them. Having said that, there is little control and regulation in the supplement sector. It is not always easy to tell if you are receiving what the product claims to contain.

In this post, we will concentrate on vitamins for dogs who suffer from anxiety. Soothing medications, you know, for those pups who need a little help calming their brains and bodies. We'll start by talking about canine anxiety, its causes, and possible remedies. Then, we'll concentrate on specific nutrients that have been found to help stressed pets.

In a nutshell: The finest dog soothing treats and supplements

Premium Care Calming Chews – Assists dogs in remaining calm without drowsiness.

Harmony at the Front of the Pack – Ideal for on-the-go

Advanced Calming Bites by Zesty Paws – Excellent for general anxiety.

Vetriscience Composure Pro – The most potent rescue relief available.

Denamarin® Advanced Chewable Tablets – Specifically designed for senior dogs.

What to expect while using dog calming pills and how to use them

It is preferable to offer vitamins to dogs who have persistent anxiety on a daily basis. Supplements for dogs with situational anxiety perform best if given 1-2 hours before the anxiety-inducing event. If you provide the supplements before your dog is already tense, they will have a greater impact. Then, re-dose your dog according to the label's directions.

Calming supplements work best in dogs who have minor general and situational anxiety. Consult your veterinarian if your dog suffers from chronic or severe anxiety. They'll know if your dog requires prescription drugs or special training. For example, if your dog's nervousness manifests as external hostility, you should consult a behaviorist.

According to research, relaxing substances are useful.

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According to research, calming supplements in any form are excellent at reducing anxiety. This is determined by monitoring the levels of stress hormones (cortisol) and happy hormones (serotonin) in a dog's bloodstream before and after the supplements are administered.

Human studies have provided us with a lot of information regarding calming supplement ingredients. However, data suggests that they have a comparable impact in dogs.

The active compounds you should be aware of

There are a variety of natural drugs that can help dogs cope with anxiety. Some supplements contain a combination of these components, while others may only contain a single ingredient. Calming supplements are most effective when they contain a variety of substances that work together to relieve anxiety. We'll go through some of these particular elements in more detail below.

Valerian Extract

Valerian root is derived from the flowering plant Valeriana officinalis, and its mechanism of action is unknown. Most researchers believe it raises GABA (gamma-aminobutyric acid) levels in the brain. GABA has a soothing impact on the brain, allowing your dog to unwind.

Valerian root is most effective for situational anxiety, such as trips to the vet or thunderstorms. Because the supplement has a sedative effect, your dog may become drowsy.


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Melatonin can also improve GABA function in the brain and diminish feelings of fear. It is most commonly used for its sedative qualities, which can aid in brain relaxation. Melatonin is helpful for dogs when administered for situational anxiety, such as during thunderstorms, fireworks, or vet visits. It can also be used to help with automobile rides or to alleviate the symptoms of separation anxiety.

Vets usually regard melatonin to be safe, although there haven't been many canine-specific research. Always with your veterinarian before giving your dog melatonin supplements.


Green tea contains the amino acid L-theanine. It produces a relaxing effect by boosting serotonin and dopamine levels in the brain. It has been shown in humans to reduce tension and heart rate in cases of chronic worry.

Most calming supplements for dogs contain L-theanine, which can be used to treat a range of stressful situations. Give your dog a vitamin approximately an hour before a stressful occasion.


Low L-tryptophan levels in the body have been linked to anxiety, mood disorders, and depressive symptoms. So it stands to reason that increasing tryptophan levels in the body would lower anxiety symptoms. Tryptophan also boosts the quantity of serotonin, or the happy hormone, in your dog's brain.

It can also be turned into melatonin, which has the ability to reduce fear. Tryptophan has even been demonstrated in dog experiments to alleviate symptoms of anxiety caused by noise phobias. When dogs were given Tryptophan, they calmed down within 30 minutes and the effects lasted for up to 4 hours.


Chamomile is a plant extract that has anti-inflammatory, antispasmodic, and muscle-relaxing qualities. It can help with relaxation because it has modest sedative qualities, which can help ease anxiety. It can also help with anxiety-related gastrointestinal issues such gas, discomfort, and bloating. This is significant since many anxious dogs are prone to digestive issues.

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CBD Oil/Hemp Oil

These days, hemp oil and CBD oil are extremely popular among dog owners. While there is anecdotal evidence that CBD is useful, more research is needed. Scientific evidence has yet to establish its consistent efficacy and safety profile.

"Cannabis-derived products that have been recommended as medicinal agents for use in animals to date have not followed the typical process to FDA approval," according to the American Veterinary Medical Association (AVMA). According to the AVMA, "latest reports of lab testing indicate that a large fraction of products now available on the market are labeled erroneously in terms of both the identification and amount of active ingredient discovered within the product."

This indicates that the majority of the products being sold to you have not been approved by the FDA. Furthermore, you may or may not be getting your money's worth in terms of quality ingredients. As a result, the veterinary community continues to fund additional studies to assist examine the efficacy and safety of CBD oil in dogs.

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If you do try CBD oil on your dog, make sure it's made exclusively for dogs and follow the label directions exactly to reduce the possibility of your dog having an allergic response. Never give your dog human-labeled CBD oil or any product containing marijuana, as they are potentially hazardous to canines. Also, ensure that the CBD oil comes from a hemp producer rather than a marijuana grower.

You should also be aware of the legality of CBD oil usage. CBD oil derived from hemp that contains less than 0.3 percent 19-tetrahydrocannabinol (THC), the psychoactive component of marijuana, is lawful in the United States. Because of the risk to their medical license and the existing ambiguity surrounding this topic, your veterinarian may or may not be willing to discuss CBD oil as a method of treating canine anxiety with you.

Read our CBD oil for dogs breakdown.


Passionflower is a natural herbal medication that is thought to improve mood. It has a calming effect on your dog, however it works best if given before a trigger sets them off. When used as directed on the product label, it is extremely safe. It is frequently made as a liquid herbal extract that can be conveniently administered using a dropper bottle.


Colostrum is a soothing substance that has been clinically demonstrated to be useful in dogs. Colostrum is a milk protein that is derived from a breastfeeding female's first milk. Cows are usually utilized to obtain the colostrum used in supplements.

Alpha-casozepine (casein) and colostrum calming complex are the two main milk proteins employed for this purpose (C3). Colostrum is the most effective treatment for situational anxiety.

Anxiety symptoms in dogs

Some canines are more anxious than others, just as some people are. Some dogs may have relatively minor anxiety, but others may have more severe anxiety. It is crucial to know that dogs can experience anxiety at any age. It can appear as early as puppyhood in some cases. Other instances, it will appear later in life for no apparent cause.

Anxiety symptoms in dogs include:

Incorrect urination or defecation

Excessive dependency

Trembling and shaking

Panting excessively

Pacing, restlessness

Excessive grooming and licking

Schedule an appointment with your veterinarian if you've noticed any of these behavioral changes. This is to ensure that your dog's behavior is not due to an underlying medical condition. Before concluding that anxiety is the underlying issue, your veterinarian can perform blood testing and a comprehensive evaluation on your dog.

Medical diseases such as kidney illness, for example, might induce an increase in urine. That means there will most likely be mishaps around the house. Some dogs suffering from severe diseases, such as arthritis or back pain, may exhibit excessive panting, shaking, restlessness, and even increased aggression.

For these reasons, it's always a good idea to consult with your veterinarian before attempting any at-home cure. There could be an underlying issue that necessitates more in-depth treatment.

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Anxiety's sources

Anxiety in dogs can be caused by a variety of factors. Every dog is unique, and the underlying reason of anxiety can be as diverse as the dogs themselves. Anxiety in your dog can often be caused by a mix of factors. Furthermore, some dogs are genetically prone to anxiety, and no matter how carefully you socialize them or expose them to new experiences in their lives, they will develop behavioral disorders.

Fear and separation anxiety are the most prominent causes of anxiety in dogs. There is also an age-related shift in the brains of some elderly dogs that might lead them to act worried.

Fear-induced anxiety

Anything that your dog is afraid of can create fear-related anxiety. This includes any type of stimuli or setting that is frightening to your dog. This may include any of the following:

Thunder or fireworks are examples of loud noises.

new scenarios or locations

People who are new or different

Dogs or other animals that are new or different

Visual stimuli, such as new objects they haven't seen before or objects that resemble an object with which they identify an unfavorable scenario

Going to the veterinary clinic is an example of a specific situation.

Rides in automobiles

These concerns might sometimes develop as a result of distressing experiences your dog has undergone. For example, if your dog had a horrible experience at the vet or all they recalled about their vet visit was being probed and prodded, they will most likely be scared every time they are taken back there- they will remember both the sights and the scents.

These concerns may also develop if your dog was not properly socialized as a puppy. Puppies must be exposed to a wide range of people, situations, things, and other canines at a vital period of development so that they are not frightened later in life.

Anxiety about separation

When dogs with separation anxiety are left alone, they become quite frightened and nervous. This can occur if they are separated from their owner or primary caregiver. However, some dogs may experience separation anxiety if they are removed from an animal friend or partner.

Dogs suffering from separation anxiety may urinate or defecate within the house. They may also bark or whine incessantly, causing annoyance to their neighbors. They can also be damaging to the home's furnishings, or even worse, to themselves.

Age-related anxiety

As dogs age, they develop a brain condition comparable to that of individuals suffering from Alzheimer's disease. Canine Cognitive Dysfunction is a syndrome that can cause disorientation, restlessness, and a disruption in typical sleep-wake habits. It can also cause a disruption in their taught skills, including as toilet training outside or other training they were previously very excellent at.

As you can imagine, an elderly dog that suddenly forgets he needs to go potty outdoors and sleep at night can be a real pain for his owner. These dogs are typically restless and worried throughout the night, forcing their owners to miss out on essential sleep.

Anxiety or bottled-up energy?

Despite the fact that anxiety-related problems are very frequent in dogs, it is critical to get to know your dog. Some pet owners may believe that their dog is anxious when, in fact, their dog is merely hyperactive and needs more engagement and enrichment in their lives.

With our schedules becoming increasingly hectic, it can be difficult to find enough time to let your dog to expend all of their physical and mental energy. However, you may be pleasantly delighted to learn that if you discover ways to keep your dog busy, their anxiety-like tendencies may begin to subside.

Take your dog on frequent, fast-paced walks or jogs. Consider enrolling them in an agility class or allowing them to attend doggie daycare on specific days of the week. This is especially crucial for specific dog breeds, such as working and sporting breeds.

7 methods for relieving your dog's nervousness

If your vet determines that your dog does, in fact, suffer from anxiety, there are several therapies available. It's also worth noting that anxiety is a complicated ailment that's best addressed with a variety of techniques.

Training is most likely the most crucial aspect of addressing canine anxiety. Positive reinforcement trainers and/or veterinary behaviorists in your area can be found through your veterinarian.

The trainer or behaviorist can work with you and your dog to determine what is causing your dog's nervousness. Many of them will also provide in-home consultations, which are the greatest method to have a deeper understanding of your dog's triggers and what can be done to counter-condition your dog's behavior.

If you can't afford a trainer, there are many of desensitization and counter-conditioning strategies you may use with your dog at home. Consult your veterinarian about what you can do to especially help your dog's nervousness. Always remember that positive reinforcement is essential in this situation. Punishment or negative reinforcement in training may exacerbate your dog's nervousness.


Adequate exercise for your dog is critical to their mental health. Allowing them to go around, interact with other dogs, and have lots of time to play with you will make them feel more confident and content. Not to mention that exhausting them will leave them with less free time to dwell on their fears or destructive activities. They might even sleep better at night.

Stimulation of the environment

Environmental stimulation, like exercise, can help keep your dog's mind occupied during the day, reducing the impacts of anxiety. If your dog is driven by treats and food, you can supply them with a variety of enrichment items while you are away throughout the day.

Fill a huge Kong toy with peanut butter, freeze it overnight, and then give it to your dog during the day. You may also put kibble or treats in a puzzle ball that they must push around or hurl up in the air to figure out how to get the tasty food out. Both are excellent strategies to keep their minds stimulated.

If your dog has a favorite toy, try to offer it to them exclusively during times of worry so they can focus on the object rather than their fear. Surprisingly, there is even music designed expressly for dogs to help them relax.

Dog interactive cameras are another method for environmental stimulation. These can be beneficial to some puppies. Some dogs would most likely like being able to engage with their owners digitally by hearing their voice or even seeing their face. However, this may not be the greatest tool for every dog, and it may aggravate some dogs' separation anxiety, especially if they can only hear your voice but cannot see you.


Thundershirts are tight-fitting shirts that apply consistent, mild pressure to your dog. They help to alleviate your dog's uneasiness and restlessness and can be a valuable tool in your toolbox for calming your dog down. Thundershirts are effective for many dogs, but not all. However, you won't know if it works unless you try it. The company often provides a money-back guarantee, so purchasing one to test it out is worthwhile.


Canine pheromones are chemical hormones that dogs emit in various settings, usually through scent. Mother dogs emit relaxing pheromones that are passed on to their offspring. Fearful pheromones are emitted by dogs in stressful situations, such as at the vet clinic.

Adaptil is a product that emits dog's natural joyful and reassuring pheromones. When your dog breaths in and smells the scent of the pheromones, it relaxes and feels at rest. They come in a variety of formats, including plug-in diffusers, sprays, and collars that your dog can wear around their neck.

Medications on prescription

Prescription drugs are likely to be required if a dog's mind is so anxious to be trained. Some dogs only require short-term treatment while they learn coping techniques. Others may require treatment for the rest of their lives.

Trazadone, Fluoxetine, and Clomipramine are the most commonly prescribed medications nowadays. Before prescribing one of these treatments, your veterinarian will need to evaluate your dog. Typically, blood work is all that is required to ensure that your dog's organs are operating properly.

Supplements for relaxation

Calming pills can be used to help calm your dog down. The effectiveness of these devices varies from dog to dog.

These items are often manufactured from natural ingredients and are safe for your dog to consume. Having said that, any dog could be allergic to anything that enters their body. When you give your dog something new, keep a tight eye on them during the first 24-48 hours. If you observe any hives, vomiting, or diarrhea, contact your veterinarian.

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